IGF-1 DES, or Insulin-Like Growth Factor 1 DES (1-3), is a truncated form of Insulin-Like Growth Factor 1 (IGF-1). This peptide boasts a shorter amino acid sequence, with the first three N-terminal amino acids cleaved, resulting in an overall increase in its biological activity.
The primary function of IGF-1 DES lies in its ability to stimulate growth and development of cells, primarily muscle and bone cells. This is achieved through its role in protein synthesis, where it acts as a mediator in the growth hormone (GH) signaling pathway. Upon GH binding to its receptor, IGF-1 is released, promoting cellular growth and proliferation.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4978042/
[2] https://pubmed.ncbi.nlm.nih.gov/15985695/
[3] https://www.sciencedirect.com/science/ article/abs/pii/S156816370500005X
[4] https://pubmed.ncbi.nlm.nih.gov/11175789/
[5] https://pubmed.ncbi.nlm.nih.gov/30953403/
[6] https://pubmed.ncbi.nlm.nih.gov/20215428/
[7] https://pubmed.ncbi.nlm.nih.gov/22503992/
[8] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6708115/
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